Ethyl 4,4-difluoro-3-oxobutanoate factory CAS NO.352-24-9

    we have a land of 3 hectares and an experienced R&D team.

    We establish closely cooperative relationships with Zhejiang University, Zhejiang University of Science and

Technology, Emden-Leer of Germany, etc. 

Company Name: Nantong Baokai Chemical Co., Ltd

Year Established: 2006

Main products: fluoro-pharmaceutical intermediates

1. Introduction of Ethyl 4,4-difluoroacetoacetate (CAS No. 352-24-9)

Our Ethyl 4,4-difluoroacetoacetate products are mainly with the assay 98%. For being one kind of colorless transparent liquid, it should be stored in a cool, dry, well ventilated place, with the package of 50-200kg/drum. Besides, its transportation information is flammable liquid, class: 3; UN1993. As to the application, it could be applied as the intermediates. Our Min. Order of Ethyl 4,4-difluoroacetoacetate 98% is 1 Kilogram.



For being stable under recommended transport or storage conditions, Ethyl 4,4-difluoroacetoacetate should be avoided from heat, hot surfaces, sources of ignition, and flames. And it is being incompatible with strong oxidising agents and strong acids.

2. Properties of Ethyl 4,4-difluoroacetoacetate (CAS No. 352-24-9)

Physical properties of Ethyl 4,4-difluoroacetoacetate are as below: (1)H bond acceptors: 3; (2)H bond donors: 0; (3)Freely Rotating Bonds: 5; (4)Index of Refraction: 1.375; (5)Molar Refractivity: 31.93 cm³; (6)Molar Volume: 139.4 cm³; (7)Surface Tension: 26.7 dyne/cm; (8)Enthalpy of Vaporization: 40.65 kJ/mol; (9)Vapour Pressure: 1.49 mmHg at 25°C; (10)Refractive index: 1.407.3. Structure Descriptors of Ethyl 4,4-difluoroacetoacetate (CAS No. 352-24-9)

3. Structure Descriptors of Ethyl 4,4-difluoroacetoacetate (CAS No. 352-24-9)

You could convert the following datas into the molecular structure:
InChI:InChI=1S/C6H8F2O3/c1-2-11-5(10)3-4(9)6(7)8/h6H,2-3H2,1H3
InChIKey:InChIKey=CBDPWKVOPADMJC-UHFFFAOYSA-N
Smiles:O=C(OCC)CC(=O)C(F)F

4. Preparation of Ethyl 4,4-difluoroacetoacetate (CAS No. 352-24-9)

Ethyl 4,4-difluoroacetoacetate could be produced by many different methods. This chemical could be obtained by the following process: Acetic acid ethyl ester reacts with difluoro-acetic acid ethyl ester using reagent of lithium diisopropylamide in the solvent of diethyl ether under the reaction temperature of -70 °C for 4 hours to give Butanoic acid,4,4-difluoro-3-oxo-, ethyl ester . The yield is about 82%.

5. Safety Information of Ethyl 4,4-difluoroacetoacetate (CAS No. 352-24-9)

Hazard Codes: F,Xi
RIDADR: 1993
Hazard Note: Flammable
HazardClass: IRRITANT, FLAMMABLE

(1). Highly flammable. This chemcial may catch fire in contact with air, only need brief contact with an ignition source, have a very low flash point or evolve highly flammable gases in contact with water. And it could causes burns.
(2). Irritant. For being irritating to eyes and respiratory system, Ethyl 4,4-difluoroacetoacetate may cause inflammation to the skin or other mucous membranes. Therefore, you should wear suitable protective clothing, gloves and eye/face protection. Besides, if in case of contact with eyes, rinse immediately with plenty of water and seek medical advice.