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Home > Products >  Difluoroacetic acid

Difluoroacetic acid CAS NO.381-73-7

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Quick Details

  • ProName: Difluoroacetic acid
  • CasNo: 381-73-7
  • Molecular Formula: C2H2F2O2
  • Appearance: Colorless transparent liquid
  • Application: Drug intermediates
  • PackAge: 25KG (50KG, 100KG, 250KG) / Drum, (Pla...
  • ProductionCapacity: Metric Ton/Day
  • Purity: >=98%
  • Storage: store in a cool,dry. Well ventilated p...
  • Transportation: UN 3265 8/PG 2
  • LimitNum: 0 Metric Ton


    we have a land of 3 hectares and an experienced R&D team.


    We establish closely cooperative relationships with Zhejiang University, Zhejiang University of Science and


Technology, Emden-Leer of Germany, etc. 


Company Name: Nantong Baokai Chemical Co., Ltd


Year Established: 2006


Main products: fluoro-pharmaceutical intermediates


1. Introduction of Difluoroacetic acid (CAS No. 381-73-7)

Our Difluoroacetic acid products are mainly with assay >=98%. For being one kind of colorless transparent liquid, its transport information is UN 3265 8/PG 2. This chemical is incompatible with Strong oxidizing agentsStrong oxidizing agents, Strong bases, and it should be avoided with heat, flames and sparks.


Product name:


Other name:

Difluoroacetic acid



Molecular Structure:




Molecular Weight:



Colorless transparent liquid

Boiling Point:


Melt Point:




Quality Item




Drug intermediates


25KG (50KG, 100KG, 250KG) / Drum, (Plastic lining steel drum) or as your requirement.

2. Properties of Difluoroacetic acid (CAS No. 381-73-7)

Properties of Difluoroacetic acid are as below: (1)ACD/LogP: 0.22; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.39; (4)ACD/LogD (pH 7.4): -3.53; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 37.3; (13)Index of Refraction: 1.314; (14)Molar Refractivity: 13.165 cm3; (15)Molar Volume: 67.447 cm3; (16)Polarizability: 5.219×10-24cm3; (17)Surface Tension: 24.4099998474121 dyne/cm; (18)Density: 1.424 g/cm3; (19)Flash Point: 36.135 °C; (20)Enthalpy of Vaporization: 41.208 kJ/mol; (21)Boiling Point: 136.137 °C at 760 mmHg; (22)Vapour Pressure: 4.39200019836426 mmHg at 25°C.

3. Structure Descriptors of Difluoroacetic acid (CAS No. 381-73-7)

You could convert the following datas into the molecular structure:
(1). InChI:InChI=1S/C2H2F2O2/c3-1(4)2(5)6/h1H,(H,5,6)
(3). Smiles:C(C(F)F)(O)=O

4. Safety Information of Difluoroacetic acid (CAS No. 381-73-7)

Hazard Codes C
RIDADR UN 3265 8/PG 2
WGK Germany 3
RTECS AG9900000
Hazard Note Corrosive
HazardClass 8
PackingGroup II
HS Code 29159080
Corrosive: This chemcial may destroy living tissue on contact. And it is irritating to respiratory system.

Below are the according measure to protect yourself.
(1). In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
(2). Wear suitable protective clothing, gloves and eye/face protection45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).

5. Use of  Difluoroacetic acid (CAS No. 381-73-7)

Difluoroacetic acid could react to produce difluoroacetyl chloride, with the following condition: reagent of phosphorus pentachloride.

Use of  Difluoroacetic acid

6. Synthesis of Difluoroacetic acid (CAS No. 381-73-7)

Alanine could react with difluoroacetic acid anhydride to produce 2-difluoromethyl-4-methyl-2H-oxazol-5-one and Difluoroacetic acid. This reaction could happen in the following condition: yield of 43 %; other condition of 1). 0 °C, 40 min; 2.) 90 °C, 2 h.

Synthesis of Difluoroacetic acid

7. Toxicity of Difluoroacetic acid (CAS No. 381-73-7)



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